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RotaFlow and CentriMag Extracorporeal Membrane Oxygenation Support Systems as Treatment Strategies for Refractory Cardiogenic Shock
Author(s) -
Loforte Antonio,
Pilato Emanuele,
Martin Suarez Sofia,
Folesani Gianluca,
Jafrancesco Giuliano,
Castrovinci Sebastiano,
Grigioni Francesco,
Marinelli Giuseppe
Publication year - 2015
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.12480
Subject(s) - medicine , cardiogenic shock , extracorporeal membrane oxygenation , odds ratio , myocardial infarction , cardiology , heart transplantation , packed red blood cells , heart failure , confidence interval , refractory (planetary science) , anesthesia , blood transfusion , physics , astrobiology
Background RotaFlow and Levitronix CentriMag veno‐arterial extracorporeal membrane oxygenation (ECMO) support systems have been investigated as treatment for refractory cardiogenic shock (CS). Methods Between 2004 and 2012, 119 consecutive adult patients were supported on RotaFlow (n = 104) or CentriMag (n = 15) ECMO at our institution (79 men; age 57.3 ± 12.5 years, range:19–78 years). Indications for support were: failure to wean from cardiopulmonary bypass in the setting of postcardiotomy (n = 47) and primary graft failure (n = 26); post‐acute myocardial infarction CS (n = 11); acute myocarditis (n = 3); and CS on chronic heart failure (n = 32). Results A central ECMO setting was established in 64 (53.7%) patients while peripherally in 55 (46.2%). Overall mean support time was 10.9 ± 8.7 days (range:1–43 days). Forty‐two (35.2%) patients died on ECMO. Overall success rate, in terms of survival on ECMO (n = 77), weaning from mechanical support (n = 51;42.8%) and bridge to heart transplantation (n = 26;21.8%), was 64.7%. Sixty‐eight (57.1%) patients were successfully discharged. Stepwise logistic regression identified blood lactate level and CK‐MB relative index at 72 h after ECMO initiation, and number of packed red blood cells (PRBCs) transfused on ECMO as significant predictors of mortality ( p = 0.011, odds ratio [OR] = 2.48; 95% confidence interval [CI] = 1.11–3.12; p = 0.012, OR = 2.81, 95% CI = 1.02–2.53; and p = 0.012, OR = 1.94; 95% CI = 1.02–5.21; respectively). Central ECMO population had a higher rate of continuous veno‐venous hemofiltration (CVVH) need and bleeding events when compared with the peripheral setting. Conclusions Patients with a poor hemodynamic status may benefit by rapid insertion of veno‐arterial ECMO. The blood lactate level, CK‐MB relative index and PRBCs transfused should be strictly monitored during ECMO support. doi: 10.1111/jocs.12480 (J Card Surg 2015;30:201–208)