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Use of Fibrin Sealants in Cardiovascular Surgery: A Systematic Review
Author(s) -
Rousou John A.
Publication year - 2013
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.12099
Subject(s) - medicine , sealant , fibrin , fibrin glue , fibrin tissue adhesive , hemostasis , surgery , clinical trial , platelet rich fibrin , pathology , chemistry , organic chemistry , immunology
Abstract Background Fibrin sealants are used for hemostasis and tissue adherence. Aim of Study This systematic review summarizes published clinical data for fibrin sealant use in cardiovascular surgery. Methods A literature search for the following terms was conducted using PubMed and EMBASE: (TISSEEL or Tissucol or Beriplast P or Evicel or Quixil or Crosseal or Reliseal or Fibringluraas or Bolheal or Tachosil or Vivostat or Vitagel or Artiss or “fibrin glue” or “fibrin sealant” or “fibrin tissue adhesive”) and (cardiac or cardiovascular or vascular or heart or coronary or surgery). Case reports and series were excluded; although reports of controlled trials were preferred, uncontrolled trial data were also considered. Results Clinical trials and chart review analyses of fibrin sealants were identified and summarized. Although clinical trial data were available for other agents, the majority of published studies examined TISSEEL. Overall, TISSEEL and other fibrin sealants showed improvements over standard of care or control groups for a variety of predefined endpoints. Safety findings are also summarized. Conclusions Data from these studies showed that fibrin sealants were well tolerated and provided effective hemostasis in a range of cardiac and aortic surgeries. doi: 10.1111/jocs.12099 (J Card Surg 2013;28:238–247)