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Gene Therapy for Vein Graft Failure
Author(s) -
Wang XiaoWen,
Zhao XingJi,
Xiang XiaoYong
Publication year - 2013
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/jocs.12075
Subject(s) - medicine , genetic enhancement , vein , surgery , gene , genetics , biology
The main pathologenesis of vein graft restenosis is neointimal hyperplasia associated with vascular smooth muscle cell migration and proliferation. Gene therapy offers a novel treatment method for reducing or delaying early thrombosis, intimal hyperplasia, and late atherosclerosis. In this review, we will (1) describe sequential pathologies of vein graft disease; (2) summarize the applications of gene therapy in vein graft restenosis; and (3) discuss novel gene therapy for vein graft failure. doi: 10.1111/jocs.12075 (J Card Surg 2013;28:144–147)
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