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Clinical update on cutaneous and subcutaneous sarcomas
Author(s) -
Kumari Jyoti,
Das Kinnor,
Patil Anant,
Babaei Mahsa,
Cockerell Clay J.,
Goldust Mohamad
Publication year - 2023
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.15369
Subject(s) - medicine , dermatology , clinical trial , sarcoma , medline , radiation therapy , disease , systemic therapy , surgery , pathology , cancer , breast cancer , political science , law
Background Cutaneous sarcomas are uncommon cancers that can have a wide range of clinical symptoms and lead to considerable cutaneous as well as systemic morbidity. Aim The objective of this review article is to discuss epidemiology, clinical features, diagnosis, and therapy of different types of cutaneous sarcomas. Material and methods Literature was screened to retrieve articles from PubMed/Medline and Google Scholar and related websites. Cross‐references from the relevant articles were also considered for review. Review articles, clinical studies, systematic reviews, meta‐analyses, and relevant information from selected websites were included. Results and discussion Cutaneous sarcomas have a negative effect on the quality of life. In their diagnosis, clinical presentation and histological evaluation are crucial. Complete surgical removal is the solution for more or less all cutaneous and subcutaneous sarcomas. The prognosis for cutaneous sarcomas is generally favorable since they tend to recur locally with distant metastases only on rare occasions. Patients having advanced disease should be treated in the setting of clinical trials if possible; choices include radiation therapy and systemic medicines. The value of innovative immunotherapy cannot be determined decisively at this time due to a paucity of relevant trials. Conclusion As cutaneous sarcomas are rarely diagnosed based on clinical findings, histology plays an important role in the diagnosis. They have a relatively favorable prognosis if treated properly. Patients should be treated at specialized centres.