English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Objective  Scalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS 2 ) improve clinical signs and symptoms in both scalp dandruff and SD.    Aim  The main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two‐phase treatment period.    Material and methods  The scalp microbiota and clinical efficacy were investigated in 68 subjects with mild‐to‐moderate scalp SD after an initial one‐month treatment with 2% ketoconazole, and after a 2‐month maintenance phase, either with a 1% SeS 2 ‐based shampoo or its vehicle.    Results  Thirty one subjects in the active and 37 subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (−1.75  p  < 0.05), non‐adherent (−1.5,  p  < 0.05)) flakes and erythema (scores 1.67–0.93,  p  < 0.001), in an increased fungal diversity and in a significant ( p  < 0.005) decrease of  Malassezia  spp. SeS 2  provided an additional clinical improvement (−0.8;  p  = 0.0002 and −0.7;  p  = 0.0081 for adherent and non‐adherent flakes, respectively, at Day 84) compared to the vehicle associated with a low  Malassezia  spp. count and an additional significant ( p  < 0.001) decrease of the  Staphylococcus  spp. level.    Conclusion  Selenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of  Staphylococcus  spp. in scalp SD and open possible perspectives for preventing relapses.

journal of cosmetic dermatology

Continuous clinical improvement of mild‐to‐moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide–based shampoo after an initial treatment with ketoconazole