Premium
Continuous clinical improvement of mild‐to‐moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide–based shampoo after an initial treatment with ketoconazole
Author(s) -
Massiot Philippe,
Clavaud Cécile,
Thomas Marie,
Ott Alban,
Guéniche Audrey,
Panhard Ségolène,
Muller Benoît,
Michelin Céline,
Kerob Delphine,
Bouloc Anne,
Reygagne Pascal
Publication year - 2022
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.14362
Subject(s) - malassezia , scalp , ketoconazole , shampoo , seborrheic dermatitis , dermatology , dandruff , medicine , erythema , seborrhoeic dermatitis , adverse effect , antifungal , pathology
Objective Scalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS 2 ) improve clinical signs and symptoms in both scalp dandruff and SD. Aim The main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two‐phase treatment period. Material and methods The scalp microbiota and clinical efficacy were investigated in 68 subjects with mild‐to‐moderate scalp SD after an initial one‐month treatment with 2% ketoconazole, and after a 2‐month maintenance phase, either with a 1% SeS 2 ‐based shampoo or its vehicle. Results Thirty one subjects in the active and 37 subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (−1.75 p < 0.05), non‐adherent (−1.5, p < 0.05)) flakes and erythema (scores 1.67–0.93, p < 0.001), in an increased fungal diversity and in a significant ( p < 0.005) decrease of Malassezia spp. SeS 2 provided an additional clinical improvement (−0.8; p = 0.0002 and −0.7; p = 0.0081 for adherent and non‐adherent flakes, respectively, at Day 84) compared to the vehicle associated with a low Malassezia spp. count and an additional significant ( p < 0.001) decrease of the Staphylococcus spp. level. Conclusion Selenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of Staphylococcus spp. in scalp SD and open possible perspectives for preventing relapses.