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A new era of moisturizers
Author(s) -
Chandan Neha,
Rajkumar Jeffrey R.,
Shi Vivian Y.,
Lio Peter A.
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.14217
Subject(s) - medicine , barrier function , moisturizer , atopic dermatitis , microbiome , transepidermal water loss , skin barrier , dermatology , pharmacology , bioinformatics , chemistry , biology , pathology , stratum corneum , food science , microbiology and biotechnology
Background Moisturizers traditionally function to replenish both the intercellular lipid lamella and natural moisturizing factors, and form a hydrolipid film on the skin surface to decrease transepidermal water loss and improve hydration. As we continue to identify epidermal lipid imbalance in patients with atopic dermatitis, we turn to the use of bioactive ingredients in moisturizers for improving barrier repair and function. Methods This review aims to explore the modern use of moisturizers in targeting various components of the skin barrier, dampening immune response, and restoring microbial balance. We conducted a balanced and comprehensive narrative review of the literature. Studies were identified by searching electronic databases (MEDLINE and PubMed), focusing on studies and trials regarding moisturizers that include endocannabinoids, bioactive lipids, anti‐inflammatory agents, antioxidants, and microbiome modulators. Only articles published in English language were included. Results The aforementioned ingredients exert additional biological effects to improve skin function by upregulating lipid synthesis, decreasing neurosensory transmission of itch signals, reversing oxidative stress, decreasing inflammatory cell activity and cytokine release, and modulating skin microbiota. The shift from traditional moisturizers to those with bioactive ingredients, anti‐inflammatory agents, and microbiome modulating effects opens a realm of possible therapeutic options for patients with barrier‐defective cutaneous conditions. Conclusion Focusing on the disrupted skin barrier as a target for both prevention and treatment and incorporating a combined strategy that utilizes the aforementioned agents to tackle barrier dysfunction from different angles remains a promising area for clinical impact in dermatology.