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Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post‐inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Author(s) -
Campos Valeria,
Pitassi Luiza,
Kalil Célia,
Gonçalves Júnior José Euzébio,
Sant’Anna Beatriz,
Correia Priscila
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.14016
Subject(s) - glycolic acid , medicine , acne , salicylic acid , hyperpigmentation , citric acid , dermatology , gastroenterology , lactic acid , chemistry , biochemistry , genetics , organic chemistry , bacteria , biology
Background Acne is a chronic disease that affects the pilosebaceous follicle and is characterized by the presence of non‐inflammatory and/or inflammatory lesions, affecting both adolescents and adults. Inflammatory acne lesions are capable to increase their melanin production and promote a post‐inflammatory hyperchromia. Aims To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post‐inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris. Patients/Methods A single‐center, prospective, open‐label clinical study included 42 subjects, from both genders, presenting acne (grade I or II), oily skin and a clinical diagnosis of acne post‐inflammatory hyperpigmentation. The study was conducted for 56 days, with clinical (skin quality and the number of post‐inflammatory hyperchromic lesions) and instrumental (Sebumetry) evaluations after 7, 28, and 56 days of treatment. Standardized pictures were obtained using a VISIA‐6 ® device. Results A significant decrease in the grade of post‐inflammatory hyperchromic lesions was observed after 28 and 56 days, while the number of lesions decreases by 29.4% after 56 days ( p < 0.001). Sebumetry values showed a significant decrease of 30.7% in the oiliness after 7 days of treatment, and then stable during the study conduction period of 56 days ( p < 0.001 for all measurements). Conclusions The daily treatment using the investigational product showed an interesting decrease both in the grade and the number of post‐inflammatory hyperchromia acne lesions after 56 days, and in the oiliness after 7 days, being stable for all study period.