Premium
Botulinum toxin in treating Hailey‐Hailey disease: A systematic review
Author(s) -
Zhang Hanlin,
Tang Keyun,
Wang Yuchen,
Fang Rouyu,
Sun Qiuning
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13963
Subject(s) - hailey–hailey disease , medicine , botulinum toxin , intertriginous , dermatology , disease , cochrane library , surgery , pemphigus , randomized controlled trial
Background Hailey‐Hailey disease is a rare disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. Botulinum toxin has been used in the treatment of Hailey‐Hailey disease. Aims This study aimed to examine all published articles on botulinum toxin in the treatment of Hailey‐Hailey disease, and to evaluate its efficacy and safety. Methods PubMed, Embase, Cochrane Library, and Web of Science were used to identify eligible articles on August 8, 2020. The searching strategy was “(Hailey Hailey or Hailey‐Hailey or pemphigus) and botulinum.” Results Sixteen articles including 38 patients described the use of botulinum toxin in treating Hailey‐Hailey disease. Only one case had no response, while the other patients all had partial or complete remission. No side effects were reported. Nine articles including 10 patients mainly described other treatment options, and the patients were only treated with botulinum toxin previously. Their responses to botulinum toxin were limited: one was mild improvement, one was partial response, and the other eight failed. Conclusion Botulinum toxin is not almighty, but a promising alternative option. We recommend botulinum toxin as an adjuvant or supplemental treatment modality for severe and recalcitrant Hailey‐Hailey disease. Larger studies are warranted to confirm its efficacy, safety, long‐term effects, and cost performance.