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Beneficial effects of an alkaline topical treatment in patients with mild atopic dermatitis
Author(s) -
Jurecek Ludovit,
Rajcigelova Tana,
Kozarova Andrea,
Werner Tanja,
Vormann Juergen,
Kolisek Martin
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13936
Subject(s) - medicine , atopic dermatitis , dermatology , topical medication , sensitive skin , glaucoma , ophthalmology
Background Atopic dermatitis (AD) is the most common cause of eczema. The skin condition affects millions of people worldwide. Severe cases of AD demand systemic treatment, but most AD cases rely on local therapy with topical corticosteroids, emollients, and moisturizing agents to alleviate eczema. Commonly, derma‐cosmetics with a pH around 5.5 are used to treat eczematous lesions (EL). However, evidence is currently amassing that the use of mildly alkaline topical creams is beneficial for AD‐related eczema treatment because of its effect on the inflammation in the skin. Aims To test an alkaline two‐phase care concept for the treatment of eczema. Patients/Methods An open‐label study of 25 patients with eczema associated with mild AD. Patients were treated with Alkaline Build Up Caring Cream INTENSIVE and Alkaline Build Up Caring Cream PLUS+ (both Siriderma ® ) for eight weeks. Dermatological, biochemical, and questionnaire‐based examinations were conducted prior to the trial and after its completion. Results Topical administration of slightly alkaline creams led to small and statistically insignificant increases of skin pH. Clinical examination at the end of the observation period revealed a significant decrease of total eczematous‐affected skin area, a significant decrease in average severity scores of EL, and significant improvements in patient‐reported outcome parameters. Blood tests did not reveal any significant changes, except for small but significant increases in IL‐8 and monocytes. Conclusion Mildly alkaline topical creams seem to provide soothing effects on eczema‐related skin inflammation and thus might contribute to treatment of local symptoms of eczema in patients with mild AD.