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Bioactivity of abobotulinum toxin is preserved till 2 weeks upon storage at room temperature: Half body comparative study on rabbit model
Author(s) -
Esme Pelin,
Botsali Aysenur,
Erbil Hakan,
Aksoy Okan Ali,
Caliskan Ercan
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13836
Subject(s) - potency , botulinum neurotoxin , medicine , botulinum toxin , anesthesia , neurotoxin , surgery , chemistry , toxin , zoology , biology , biochemistry , in vitro
Background Breakages of the cold chain of botulinum neurotoxin A (BONT‐A) preparations is not a rare event and occurs due to several unexpected and unintentional reasons during daily practice and intervention schedules could not be proposed due to the lack of data. Objective To investigate the heat stability of abobotulinum toxin A (AboBONT‐A) in terms of efficacy and duration of action upon storage at room temperature (25°C) for 2, 4, and 8 weeks. Methods and Materials Twenty rabbits were divided into four groups and received an injection of ideally stored AboBONT‐A (Group 1) and stored AboBONT‐A for 2 (Group 2), 4 (Group 3), and 8 weeks (Group 4) at room temperature into the anterior auricular muscle. All rabbits were followed up and photographed by weekly for 16 weeks. Grade of paralysis was evaluated by using a modified visual scoring system. Results No significant alteration was found in initial potency of stored AboBONT‐A at room temperature for up to 4 weeks. Storage at room temperature for 2 weeks did not affect the duration of action (group 2; P = .69), and faster recovery was observed in group 3 and group 4. Conclusion The bioactivity of AboBONT‐A is not altered till 2 weeks upon storage at room temperature.