z-logo
Premium
Dermatologic adverse reactions to proton‐pump inhibitors: A synthetized review
Author(s) -
Salloum Antoine,
Nasr Dayana,
Maalouf Diane
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13763
Subject(s) - medicine , esomeprazole , dermatology , drug reaction , adverse effect , lansoprazole , drug , intensive care medicine , adverse drug reaction , contact dermatitis , omeprazole , pharmacology , immunology , allergy
Background Proton‐pump inhibitors (PPIs) are one of the most prescribed drugs. Their dermatological adverse reactions are multiple and vary in severity. Aims This review discusses all reported cutaneous side effects of PPIs in order to help physicians understand them and provide appropriate management. Methods A thorough search of PubMed, Embase, and FDAAQ8 drugs websites was conducted. 56 articles including case reports, case series, and review articles of PPI‐induced cutaneous adverse reactions were selected. Data were recorded regarding patient age, gender, history, clinical manifestations, diagnostic tests, management, and clinical outcomes. Results PPI‐induced adverse skin reactions are mostly immunological and include both immediate and delayed‐type hypersensitivity reactions. These reactions are sometimes life‐threatening. All PPIs can induce immediate IgE‐mediated reactions. Most of previously published cases of delayed‐type hypersensitivity reactions have involved esomeprazole, omeprazole, and lansoprazole. Skin tests are helpful in confirming PPI‐induced hypersensitivity reactions and diagnosing potential cross‐reactivities. PPIs should also be added to our list of usual suspects when considering possible culprits for a new presentation of drug‐induced subacute lupus erythematosus. PPI‐related occupational contact dermatitis has also been numerously reported. Conclusion PPIs should be considered in our list of culprits when considering a patient with a cutaneous drug reaction, taking into account that these drugs can cause severe immunological manifestations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here