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Nano, micro particulate and cosmetic delivery systems of polylactic acid: A mini review
Author(s) -
Abu Hajleh Maha N.,
ALSamydai Ali,
AlDujaili Emad A. S.
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13696
Subject(s) - polylactic acid , lactic acid , drug delivery , biocompatible material , nanotechnology , materials science , biodegradable polymer , polymer , microsphere , emulsion , chemistry , biomedical engineering , organic chemistry , chemical engineering , medicine , engineering , biology , bacteria , genetics , composite material
Background Poly lactic acid and its copolymers are considered to be the preferred substrates for drug delivery devices. Poly lactic acid is a biocompatible, biodegradable and nontoxic polymer. It was approved by Food and Drug Administration and thought to be among the most attractive polymeric candidates intended for controlling drug delivery. It was utilized for the development of devices for the delivery of small molecules, proteins, genes, vaccines, anticancer drugs, and macromolecules. Objectives and methods This manuscript lists the different techniques for synthesizing poly lactic acid‐based nano and microparticles such as emulsion‐based methods, precipitation‐based methods, direct compositing methods, in situ forming micro‐particles, and microfluidic technique. Conclusions In addition, it describes the application and use of poly lactic acid in biomedical and cosmetic delivery systems.