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A randomized, triple‐blind, placebo‐controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity
Author(s) -
Evans Malkanthi,
Lewis Erin D.,
Zakaria Nisrine,
Pelipyagina Tetyana,
Guthrie Najla
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13676
Subject(s) - wrinkle , medicine , placebo , skin aging , placebo controlled study , visual analogue scale , randomized controlled trial , surgery , dermatology , double blind , pathology , gerontology , alternative medicine
Background Collagen is the primary component in human skin. With age, there is loss of skin elasticity and collagen, resulting in wrinkle formation and reduction in skin appearance. Aims The objective of this randomized, triple‐blind, placebo‐controlled study was to evaluate the safety and efficacy of a hydrolyzed marine collagen (Vinh Wellness Collagen, VWC) on aspects of skin health and quality in women between 45 and 60 years of age. Patients/Methods Assessments of skin wrinkles, elasticity, and self‐reported appearance were conducted using the VISIA skin analysis system, Cutometer ® , and Skin Quality Visual Analogue Scale. Outcomes were assessed at weeks 0 (baseline), 6, and 12. Results After 12 weeks, participants supplemented with VWC had a significant 35% reduction in wrinkle score ( P = .035) from baseline. Participants in the VWC group showed a 24% greater reduction in wrinkles on the right side of the face than those on placebo. A planned subgroup analysis based on age showed women 45‐54 years had a significant 20% and 10% improvement in cheek skin elasticity from baseline to week 6 ( P = .016) and 12 ( P = .022), respectively. At week 12, participants in the VWC group reported greater percentage improvements in overall skin score (9%) and wrinkle (15%), elasticity (23%), hydration (14%), radiance (22%), and firmness (25%) scores vs placebo. Conclusion Supplementation with VWC was found to be safe and well‐tolerated. The results of this study support the use of fish‐derived hydrolyzed collagen for the improvement of skin health in an aging population.