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Purple tulip extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied
Author(s) -
Hajem Neïla,
Manzato Léana,
Branchet MarieChristine,
Herlin Amélie,
Hassanaly Shalina,
Huguet Elise,
Himbert Frank,
Bernard Philippe,
Dussert AnneSophie,
Choulot JeanChristophe,
Boisnic Sylvie,
Kéophiphath Mayoura
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13583
Subject(s) - ex vivo , skin aging , human skin , in vivo , immune modulation , gene expression , fibronectin , cell , microbiology and biotechnology , chemistry , biology , immune system , medicine , dermatology , biochemistry , gene , immunology , genetics
Background Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products. Aims We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction. Methods A pangenomic study on human skin fibroblasts was carried out to analyze multiple changes in gene expression. Ex vivo studies of human skin explants exposed to ultraviolet (UV) irradiation or H 2 O 2 were performed to assess modulations of protein expression. Finally, a clinical assay was carried out to evaluate the efficacy of purple tulip extract on skin appearance and condition of aged women. Results Genetic modulation analyses led us to infer the induction of many biological functions including cell differentiation, proliferation, migration, inflammatory responses, and matrix remodeling. The ex vivo studies revealed an enhancement of the collagen network and increased expression of glycosaminoglycans (GAG), fibronectin, and collagen VI. Finally, the clinical study highlighted the potential anti‐aging properties of the purple tulip extract which decreased the relaxation of the oval face and improved skin elasticity after 28 days of treatment. Significant reductions of the length and depth of the nasolabial wrinkles were also observed. Conclusion Our genomics data on the effect of purple tulip extract on the ex vivo UV‐challenged skin showed that genes responsible for, among others, the upkeep of the skin, such as collagen induction, immune cell proliferation, and epidermal repair, were all up‐regulated. More importantly, the clinical study corroborated these data by the visible and measurable effects of the topical purple tulip extract on the aged skin of 22 women, further demonstrating the beneficial impact of the extract on aged skin.