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Clinical efficacy of dissolvable microneedles armed with anti‐melanogenic compounds to counter hyperpigmentation
Author(s) -
Avcil Muhammet,
Akman Gokhan,
Klokkers Jens,
Jeong Dohyeon,
Çelik Ayhan
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13571
Subject(s) - hyperpigmentation , niacinamide , dermatology , medicine , tolerability , bioadhesive , hyaluronic acid , melanin , melasma , ascorbic acid , pharmacology , drug delivery , chemistry , food science , materials science , biochemistry , nanotechnology , nicotinamide , adverse effect , anatomy , enzyme
Background Hyperpigmentation is a complex physiological process associated with alterations of skin color due to melanin overproduction and distribution. Both intrinsic and extrinsic factors influence discoloration with the involvement of multiple pathways in cooperative manners. Restoring natural skin color requires a multi‐targeted approach. Latest advances in anti‐melanogenic compounds and microneedle delivery system have presented opportunities for tackling hyperpigmentationsuccessfully. Aims This work was aimed at assessing the dermal tolerability and efficacy of hyaluronic acid‐based microneedle patches loaded with anti‐melanogenic actives for improvements of skin discoloration. Patients/Methods The test products consist of hyaluronic acid with niacinamide, ascorbic acid 2‐glucoside, tranexamic acid, resveratrol, 4‐n‐butyl‐resorcinol, and Halidrys siliquosa extract. In a monocentric 12 weeks clinical trial, the HA‐MNs patches were applied to the affected areas of the faces on subjects with hyperpigmented skin. The color properties of the skin were analyzed spectrophotometrically. Results The products were tolerated remarkably; none of the subjects informed any primary or cumulative skin responses. Evaluation of color related measurable skin properties provided insight into the general effectiveness: The individual topology measurements showed 51.4% noticeable improvements in hyperpigmented zones, which were also in good agreement with the personal impressions of the subjects determined by questionnaires before and after the treatments. Conclusions The concentrated blends of actives in microneedle patches act in a multi‐targeted manner, and they could be worked in a complementary fashion for the improvement of skin color and appearance. The study has established the overall convenience of the HA‐MNs with the formulation of anti‐melogenic compounds against skin discoloration.