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Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice
Author(s) -
Wang Bingying,
Tai Meiling,
Zhang Kun,
Chen Huixiong,
Gan Xiaoshuang,
Che Biao,
Abudukelimu N.,
Wang Guoping,
Xin Xuelei,
Lin Li,
Han Ping,
Peng Yi,
Du Zhiyun,
Aker Aisa Haji
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13541
Subject(s) - barrier function , dry skin , hacat , polysaccharide , inflammation , transepidermal water loss , dermatology , keratinocyte , chemistry , medicine , immunology , pharmacology , in vitro , biology , pathology , biochemistry , stratum corneum , microbiology and biotechnology
Background Dry skin is a common skin condition caused by reduction of water‐holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing. Aims It remains necessary to investigate the effects of Elaeagnus L gum polysaccharides (EAP), which are prepared from gum of Elaeagnus angustifolia L. on the epidermal permeability barrier function and their possible underlying mechanisms. Patients/Methods EAP were purified, analyzed, and tested on human keratinocyte cell line (HaCaT) and then on the skin in vivo to evaluate their antiinflammatory activities and their impacts on impaired skin barrier function. Results Histological analyses revealed that topical administration with EAP effectively attenuated dryness‐like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening. Moreover, EAP inhibited the production of various inflammatory mediators and increased AQP‐3, FLG, and LOR expression. Conclusion Our results indicated that EAP enhances epidermal permeability barrier function, and they can be used as a promising adjuvant agent in skin care cosmetics and in treating some skin disorders characterized by cutaneous inflammation and abnormal barrier function.