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Comparative physicochemical stability and clinical anti‐wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Author(s) -
Mohammadi Shima,
Shokri Javad,
Ranjkesh Mohammadreza,
Akbari Hamed Shahabaddin,
Monajjemzadeh Farnaz
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13471
Subject(s) - ascorbic acid , wrinkle , transdermal , chemistry , human skin , antioxidant , clinical efficacy , sodium ascorbate , pharmacology , vitamin c , food science , chromatography , medicine , surgery , biochemistry , gerontology , biology , genetics
Objectives Antioxidant containing cosmeceuticals are commonly prescribed products in treating wrinkles and revitalizing the skin. The aim of this study was the comparative evaluation of physicochemical stability and clinical anti‐wrinkle efficacy of transdermal emulgel preparations of sodium ascorbyl phosphate (SAP) and ascorbic acid (AA) on human volunteers. Methods Emulgel preparations containing 5% of (SAP) and or (AA) were prepared. HPLC analysis was performed for stability evaluations. Clinical anti‐wrinkle efficacy of the formulations was examined on human healthy volunteers in crow's feet area. Elasticity and digital images were recorded before and after treatment. Results Formulations with added antioxidants and kept in the refrigerator exhibited better stability characteristics. Two‐sided blind study and placebo‐controlled study showed that both actives were effective in wrinkles depth reduction and also elasticity enhancement but statistically significant difference in the efficacy of the products was not observed. Conclusion Formulations containing (AA) and or (SAP) both improved elasticity and wrinkles of the skin almost by the same extent, and it is necessary to add antioxidant stabilizing agents to both preparations to reach a desired stability.