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Collagen supplementation for skin health: A mechanistic systematic review
Author(s) -
Barati Meisam,
Jabbari Masoumeh,
Navekar Roya,
Farahmand Fariba,
Zeinalian Reihaneh,
SalehiSahlabadi Ammar,
Abbaszadeh Nasrin,
MokariYamchi Amin,
Davoodi Sayed Hossein
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13435
Subject(s) - medicine , systematic review , skin aging , psychological intervention , medline , dermatology , biochemistry , chemistry , psychiatry
Background Over the last decade, many researchers tried to evaluate the effects of collagen supplements on skin aging and surprisingly revealed that the interventions improved skin aging parameters without any inconsistency. Aim This systematic review assesses the literature regarding the effects of collagen supplements on skin health parameters in healthy and patient subjects, focusing on mechanisms of action. Methods At the first step of search in the databases, 9057 items were obtained. After removal of duplicate items, 6531 publications remained. Further screening by title and/or abstract resulted in removal of 6500 items. Finally, full texts of the 31 remained items were assessed for eligibility and 10 publications were included in this review. Results The evidences obtained from these systematic reviews indicated that oral administration of intact or hydrolyzed collagen improves clinical manifestation of skin health. Almost all of the included studies reported the beneficial effects of collagen supplementation, and no inconsistencies have been seen in this regard between studies. Conclusions In this systematic review, three different mechanisms of action were clarified for the intervention. Direct effects of collagen peptides on fibroblasts, M2‐like macrophages, and oral tolerance‐related mechanisms are the possible mechanisms for the beneficial effects of collagen supplementation.