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Protein tyrosine phosphatase nonreceptor type 22 gene polymorphism in alopecia areata: Does it have an association with disease severity?
Author(s) -
Shehata Wafaa Ahmed,
Maraee Alaa,
Kamal Heba,
Tayel Nermin,
Azmy Rania
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13412
Subject(s) - alopecia areata , ptpn22 , protein tyrosine phosphatase , genotype , allele , single nucleotide polymorphism , hair follicle , gene polymorphism , medicine , polymorphism (computer science) , immunology , biology , gene , genetics , receptor
Background Alopecia areata is a condition involving hair loss from certain or all areas of the body. It has been considered as an immune‐mediated disease, characterized by the infiltration of CD4+ and CD8+ lymphocytes in the hair follicles. Aim of the study The study aimed to assess whether protein tyrosine phosphatase nonreceptor type 22 gene single nucleotide polymorphism 1858C/T has any relationship with alopecia areata in Egyptian patients and whether it is associated with disease severity or not. Subjects and methods Protein tyrosine phosphatase nonreceptor type 22 ( PTPN22 ) C1858T gene polymorphism was identified using polymerase chain reaction‐restriction fragment length polymorphism analysis technique in 60 patients suffering from alopecia areata and 30 age‐ and sex‐matched healthy controls. Disease severity was assessed using SALT score. Results CT and TT genotypes were significantly higher in the patients’ group ( P = .005), OR = 4.38 95% CI [1.48‐12.96], with significant statistical predominance of T allele in patients, P = .003, OR = 3.86, 95% CI [1.52‐9.77]. There was also a positive significant relationship between protein tyrosine phosphatase nonreceptor type 22 genotype CT and SALT score. Conclusion PTPN22 1858T allele is associated with the development and severity of alopecia areata in Egyptians.