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Comparative skin penetration profiles of formulations including ultradeformable liposomes as potential nanocosmeceutical carriers
Author(s) -
Izquierdo María Cecilia,
Lillo Cristian R.,
Bucci Paula,
Gómez Gisela Eliane,
Martínez Luis,
Alonso Silvia del Valle,
Calienni María Natalia,
Montanari Jorge
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13410
Subject(s) - cosmeceutical , penetration (warfare) , liposome , penetration rate , human skin , chemistry , biophysics , chromatography , biochemistry , microbiology and biotechnology , biology , genetics , geotechnical engineering , operations research , engineering
Background Ultradeformable liposomes are promising carriers for cosmeceutical actives as they can be loaded with molecules of different polarities, and they present unique penetration properties. Aims While those features have already been tested, we wanted to know whether their special penetration properties could be maintained after incorporation in diverse cosmetic vehicles, including commercial products already in the market. Methods Ultradeformable liposomes loaded with a lipophilic and a hydrophilic fluorescent probe were prepared by lipid film resuspension, followed by extrusion and incorporation to different vehicles and commercial products. Penetration was determined in human and pig skin by incubation, with the Saarbrücken penetration model, followed by the recovery of the probes or by fluorescence microscopy. Results The incorporation of ultradeformable liposomes to cosmetic vehicles did not alter their penetration in most of the cases for human skin explants. Pig skin penetration presented significant differences compared with human explants. Conclusions Ultradeformable liposomes could be useful as versatile cosmeceutical carriers in final product formulations.