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High levels of Helicobacter pylori antigens and antibodies in patients with severe acne vulgaris
Author(s) -
Saleh Ramadan,
Sedky Mahmoud Ahmed,
Moustafa Dina Ali,
Abu ElHamd Mohammed
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13409
Subject(s) - helicobacter pylori , medicine , antigen , antibody , gastroenterology , feces , immunology , pathogenesis , acne , biology , dermatology , microbiology and biotechnology
Background Helicobacter pylori ( H pylori ) may play a role in the pathogenesis of extra‐intestinal disorders including dermatological diseases. Aims This study aimed to assess the levels of H pylori antigen and antibody in patients with acne vulgaris (AV). Methods This cross‐sectional study compared the levels of fecal H pylori antigen and serum H pylori antibody in 100 patients with AV and 100 age and sex‐matched healthy volunteers. Patients with AV were classified into mild, moderate, and severe according to the Global Acne Grading Scale. Levels of fecal H pylori antigen and serum H pylori antibodies were assessed using commercially available enzyme‐linked immune‐sorbent assay. Results The patients with severe AV had significantly higher levels of fecal H pylori antigen as compared to the patients with mild AV, moderate AV, and healthy controls ( P < .001). The patients with severe AV had significantly higher serum H pylori antibody as compared to the patients with mild AV, moderate AV, and healthy controls ( P = .001). The levels of fecal H pylori antigen and serum H pylori antibody in the patients with mild AV were not significantly different from those in the patients with moderate AV ( P = .49 and P = .05, respectively). Conclusion The patients with severe AV had higher levels of fecal H pylori antigen and serum H pylori antibody as compared to the patients with mild and moderate AV and with healthy controls. The indicators of H pylori infection were positively correlated with the severity and duration of AV.