Premium
Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single‐blind randomized clinical trial
Author(s) -
Shamsi Meymandi Simin,
Mozayyeni Amirhossein,
Shamsi Meymandi Manzumeh,
Aflatoonian Mahin
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13392
Subject(s) - melasma , medicine , tranexamic acid , randomization , randomized controlled trial , single blind , clinical trial , patient satisfaction , dermatology , exact test , surgery , blood loss
Abstract Background There are various treatment modalities for melasma, but none of them are effective on dermal component of melasma. Aims In this study, we decided to evaluate the efficacy of microneedling plus tranexamic acid in comparison with 4% hydroquinone in the treatment of melasma. Methods This is a single‐blind randomized clinical trial on 70 participants with 14% dropout, and therefore, 60 patients with melasma completed the study. Patients were randomized based on simple randomization in 2 groups of A (microneedling plus topical 4% tranexamic acid, monthly) and B (topical 4% hydroquinone, nightly). Evaluation of mean MASI score, patient and physician assessments was performed at 4th, 8th and12th weeks of the treatment. Statistical analysis was performed by paired t test, chi‐square test and Fisher's exact test, respectively. Results Sixty women (30 patients in each group) were completed the study. Mean MASI score in group A was significantly lower at the end of the treatment (6.84 ± 4.31) than at the baseline (12.89 ± 5.16) ( P < .01). Mean MASI score in group B was significantly lower at the end of the treatment (7.16 ± 4.38) than at the baseline (13.56 ± 4.88) ( P < .01). There was no statistical difference between 2 groups regarding MASI score, physician and patient assessments during the treatment. Percentage of patient satisfaction was significantly higher than physician satisfaction in both treatment groups ( P < .01). Conclusion In our study, the combination of microneedling with tranexamic acid did not differ from 4% hydroquinone in the treatment of melasma.