Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Background Skin aging is characterized by moderate to severe wrinkles, laxity, roughness, and volume loss as a result of cutaneous atrophy and connective tissue degradation. Plasma rich in growth factor gel (PRGF‐gel) is a novel formulation obtained from the patient's own blood that has demonstrated optimal biomechanical and bioactive properties for soft tissue restoration. Objectives Following a retrospective design, the clinical safety and efficacy of PRGF‐gel for facial volume restoration and skin rejuvenation were evaluated. Methods Twenty women clinically diagnosed for aged skin symptoms were treated with PRGF‐gel. Participants received an individualized regimen depending on their therapeutic needs. At the end of the follow‐up periods, clinical performance analysis was evaluated by standardized macrophotographs along with clinical and patient surveys based on Likert's scales. Results Based on their initial expectations, patients referred to be highly satisfied after PRGF‐gel treatment in terms of fine line amelioration, wrinkle reduction, and sagging improvement (overall satisfaction of 8/10). Pre/post‐photograph clinical evaluation showed an improvement of 2.5/3 and patients presented a noticeable face rejuvenation due to the soft tissue augmentation effect which was translated into surface texture softening and tone recovery. Conclusions Although additional randomized clinical trials should be carried out, this study provides preliminary data supporting the use of PRGF‐gel for facial volume restoration.