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Comparison of transepidermal water loss rates in subjects with skin patch test positive vs negative to skin care products
Author(s) -
Liu Dan,
Wen Si,
Huang Lining,
Wang Xiaohua,
Gong Canyi,
Li Zhiping,
Wang Hui,
Elias Peter M.,
Yang Bin,
Man MaoQiang
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13264
Subject(s) - transepidermal water loss , skin care , dermatology , sensitive skin , patch test , medicine , allergy , pathology , stratum corneum , immunology , nursing
Background Adverse cutaneous reactions to skin care products (SCP) are becoming increasingly common and may be indicative of defective permeability barrier function. Aim To determine the differences in transepidermal water loss rates (TEWL) between skin patch positive vs negative to skin care products in normal Chinese females. Methods Skin patch test reactions to nine skin care products were assessed in 65 normal Chinese females. Correlations of cutaneous reactions to a panel of nine foreign and domestic SCP with permeability barrier function and stratum corneum (SC) hydration levels were analyzed. Results Out of 65 subjects, 24 (37%) displayed positive reactions to one or more SCP. However, the occurrence of positive reactions to patch tests did not correlate with either transepidermal water loss rates or SC hydration levels. Conclusions Though a substantial proportion of normal females display adverse reactions to SCP, this problem cannot be attributed to differences in the qualities of their epidermal permeability barriers, and therefore, these reactions more likely reflect the potential adverse events of the SCP themselves. However, further studies in large cohort of both males and females would be helpful to ascertain whether TEWL levels can predict cutaneous reactions to SCP.