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Sequential peeling as a monotherapy for treatment of milder forms of acne vulgaris
Author(s) -
Zayed Amira Amin,
Sobhi Rehab Mohamed,
El Aguizy Randa Mohamed Saleh,
Sabry Dina,
Mahmoud Sara Bahaa
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13162
Subject(s) - acne , medicine , doxycycline , lesion , adjuvant , patient satisfaction , gastroenterology , dermatology , grading (engineering) , surgery , antibiotics , civil engineering , microbiology and biotechnology , biology , engineering
Background Glycolic acid (GA) and salicylic acid (SA) peels have been used separately for acne treatment, not as a sequential peel. Aim To evaluate the efficacy and safety of sequential peeling with 70% GA and 20% SA as a monotherapy and as an adjuvant to systemic doxycycline in treatment of mild to moderate acne and the effect on serum interleukin (IL) 17 and tissue IL‐1α. Patients/Methods Forty‐five mild to moderate acne vulgaris patients were randomly assigned into three groups. Group [A] underwent sequential application of 70% GA followed by 20% SA biweekly for three months. Group [B] underwent sequential peeling and doxycycline PO100 mg BD for 1 month followed by 100 OD for 2 months. Group [C] received oral doxycycline. Acne grading, lesion counting, and patient satisfaction were assessed. Serum samples and perilesional skin biopsies were obtained at onset and 2 weeks after finishing the treatment for assessment of serum IL‐17 and tissue IL‐1α. Results All groups showed statistically significant decrease in acne grading and lesion count, increase in patient satisfaction, and decrease in serum IL‐17 and tissue IL‐1 α after treatment. There was no significant difference between the 3 groups before or after treatment, except regarding patient satisfaction after treatment, which was significantly higher in groups [A] and [B] than group [C] ( P = .001). Conclusions This study recommends using sequential GA 70% and SA 20% peels in the treatment of mild or moderate acne vulgaris as a new cost‐effective mode, with low‐down time and potential safety, in noncompliant patients on medical therapy.