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Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview
Author(s) -
Ravikumar Padmini,
Tatke Pratima
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13105
Subject(s) - skin cancer , medicine , melanoma , drug delivery , dermatology , basal cell carcinoma , drug , niosome , solid lipid nanoparticle , active ingredient , cancer , basal cell , pharmacology , nanotechnology , cancer research , pathology , chemistry , materials science , biochemistry , vesicle , membrane
Background The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy‐resistant malignancies. Conventional topical products are beset with limitations, leading to lower efficacy. There is a growing need to develop topical formulations encapsulated in polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and liposomes exhibiting enhanced skin penetration and longer skin retention leading to better efficacy. Objective The objective of this article is the screening of reported novel drug encapsulated delivery systems effective topically in melanoma chemoprevention. Aim The scope of this work is to provide an overview pertaining to the development and evaluation of three exemplary drug delivery systems (DDS), namely vesicular, particulate, and specialized emulsions. Methods Topical drug delivery approaches targeting skin cancer have been reviewed and discussed. The focal point of the article is presentation of insights from published studies. Results This review focuses on the novel delivery systems in chemoprevention of melanoma with discussion highlighting on advances in topical delivery. Conclusion Literature indicates that drug‐loaded encapsulated topical formulations when compared with conventional dosage forms for skin cancer treatment exhibit greater efficacy and provide benefits like extended drug release, protection of the active ingredient against degradation, and lower skin irritation. Incorporation of phytoconstituents in newer delivery systems will be the way forward for improved topical chemoprevention strategy in melanoma. This has raised hope in making dermal therapy more useful and acceptable.