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Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study
Author(s) -
Suchonwanit Poonkiat,
Harnchoowong Sarawin,
Chanasumon gsak,
Sriphojanart Tueboon
Publication year - 2020
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.13079
Subject(s) - eyebrow , bimatoprost , medicine , hypotrichosis , dermatology , patient satisfaction , ophthalmology , surgery , intraocular pressure , biology , biochemistry , gene , ocular hypertension
Background Previous studies have proven the efficacy and safety of 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis; however, there is no comparison study between both concentrations. Aims To compare the efficacy and safety between 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis. Patients/Methods This prospective, randomized, double‐blind, split‐face clinical study was conducted in 30 patients with eyebrow hypotrichosis. Each side of eyebrow of individual patients was randomly assigned for 0.01% and 0.03% bimatoprost, applied on each eyebrow once daily. Eyebrow density, diameter, the Global Eyebrow Assessment scale, 7‐point rating scale, and patient satisfaction were evaluated. Side effects were also recorded. Results Both 0.01% and 0.03% bimatoprost significantly improved eyebrow density and diameter ( P < .05), although there were no statistically significant differences in changes in eyebrow density and diameter from baseline between both concentrations ( P = .96 and .84, respectively). Additionally, patients significantly preferred 0.03% bimatoprost in terms of clinical improvement and satisfaction ( P = .04 and .003, respectively). Conclusions Both 0.01% and 0.03% bimatoprost are effective and safe for the treatment of eyebrow hypotrichosis. Bimatoprost 0.03% is superior to its 0.01% counterpart, albeit without statistical significance.