Efficacy of dermal redensification in chronoaged face: Quantitative volumetric assessment

Background Mesotherapy for chronoaged skin shows heterogeneous results. Objectives The aim of the study was to assess the efficacy of dermal redensification on the face and neck. Methods Patients with mild‐moderate‐severe chronoaging of face and neck were included and, every 14 days, treated with four sessions of dermal redensification, consisting of 1 mL of hyaluronic acid (15 mg/mL) plus a dermo‐restructuring complex. Skin improvements were analyzed at 8 weeks for amelioration by Wrinkle Severity Rating Scale and quantification of superficial wrinkles and texture by high‐resolution 3D camera. All patients underwent a self‐assessment questionnaire and Global Aesthetic Improvement Scale. Results Thirty‐six patients were enrolled (median age 55 [42‐67] years). Eight weeks after treatment all patients reported a significant improvement, being Global Aesthetic Improvement Scale ≥2 in 69% of the subjects. Patients’ perception of improvement of their skin quality was highly satisfactory in all items explored on the self‐assessment questionnaire relating to radiance, elasticity, texture, and smoothness. Subjects with fine and moderate/deep wrinkles had an improvement >25% and 50%, respectively. Quantification of wrinkles with filters for superficial plane (1 mm) showed a statistically significant median decrease, both in width (1.53 [1.41‐1.72] mm vs 1.27 [1.12‐1.34] P  < 0.001) and depth (0.46 [0.27‐0.61] vs 0.12 [0.6‐0.18] P  < 0.001). Indentation decreased by a median of 20%. Conclusions The synergic effects of hyaluronic acid and dermo‐restructuring complex show an objective amelioration of skin texture, wrinkles, and self‐evaluation of skin appearance.