Anti‐sebum efficacy of guava toner: A split‐face, randomized, single‐blind placebo‐controlled study

Background Guava has benefit phytochemicals that are important for skin‐disorder treatment. Nevertheless, its efficacy against oily skin has never been reported. Aims The guava toner was developed and clinical evaluated. Methods The base toner was formulated, accelerated stability tested, and sensory‐evaluated in 10 volunteers. The highest preference base was incorporated with guava extract, stability examined, and skin irritation assessed in 21 volunteers by a single application close patch test. Anti‐sebum efficacy was split‐face, randomized, single‐blind placebo‐controlled evaluated in 21 volunteers for 28 days and monitored by Sebutape ® on forehead and nose. Results The stable toner base with the greatest preference (83.20 ± 1.85%) was incorporated with 3%, 4.5%, and 6% of guava extract. The toners were stable with none of skin irritation. The toner with 6% guava extract was selected for efficacy evaluation. Guava toner significantly reduced oiliness of forehead (13.10 ± 3.67%, P  < 0.05) and nose (21.43 ± 3.21%, P  < 0.001) better than the base toner. The activity on nose was significantly noted (10.72 ± 3.51%, P  < 0.05) since the 3rd week of application. Conclusions Anti‐sebum guava toner was efficiently evidence approved and suitable for a daily application to improve the efficacy.