Premium
Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris
Author(s) -
Sorour Neveen E.,
Mustafa Amany I.,
Alhusseni Naglaa F.,
Fawzy Eman,
Amer Aml G.
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12937
Subject(s) - acne , gene , genetics , enzyme , medicine , angiotensin converting enzyme , polymorphism (computer science) , dermatology , biology , genotype , biochemistry , blood pressure
Summary Background Acne vulgaris is an inflammatory disorder with a profound heterogenous aetio‐pathophysiology. ACE gene I/D polymorphism affects angiotensin‐converting enzyme activities that play a role in inflammation. However, there are no molecular genetic studies investigating the contribution of ACE gene insertion/deletion polymorphism in the genetic background of acne vulgaris. Aims The aim of this work was to reveal the relation between the ACE gene I/D polymorphism and acne vulgaris development among a sample of patients. Patients and Methods This study included 100 acne vulgaris patients in addition to 120 matched control subjects. The ACE gene I/D polymorphism was analyzed using polymerase chain reaction (PCR). Results The distribution of DD, ID genotypes, and D allele showed higher frequency in AV patients than in controls ( P < 0.001 for all). Moreover, positive family history and ACEI/D gene polymorphism (DD + ID genotypes) were considered as independent predictors for severe acne grades ( P ≤ 0.001 and 0.046, respectively) in multivariate analysis. Conclusions The current study results suggest that the D allele of the ACE I/D gene polymorphism might confer risk to AV among the studied patients. Moreover, ACE I/D gene polymorphism and positive family history were considered as independent predictors of severe AV.