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The efficacy of powdered polydioxanone in terms of collagen production compared with poly‐L‐lactic acid in a murine model
Author(s) -
Kim Chang Min,
Kim Bo Young,
Hye Suh Dong,
Lee Sang Jun,
Moon Hye Rim,
Ryu Hwa Jung
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12894
Subject(s) - polydioxanone , lactic acid , polycaprolactone , chemistry , saline , carboxymethyl cellulose , type i collagen , biomedical engineering , sodium , polymer , medicine , pathology , bacteria , genetics , organic chemistry , biology
Summary Background There are many collagen‐stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly‐L‐lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread‐lifting material due to its collagen‐forming effects. PDO in powdered form is expected to be a good material for collagen‐producing fillers. Objectives To evaluate the collagen‐producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate‐buffered saline was injected on dorsal skin of 8‐week‐old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real‐time PCR to quantify collagen and tissue growth factors. Results Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF‐β1, TGF‐β2, and TGF‐β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.