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The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea
Author(s) -
Bageorgou Fotini,
Vasalou Varvara,
Tzanetakou Vasiliki,
Kontochristopoulos George
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12724
Subject(s) - tranexamic acid , medicine , rosacea , tolerability , erythema , dermatology , antifibrinolytic , surgery , anesthesia , blood loss , adverse effect , acne
Summary Background Erythematotelangiectatic rosasea is a common,chronic, relapsing disease characterized mainly by vascular components, for which many therapies may exist but with limited efficacy. Objectives We decided to test the efficacy of tranexamic acid when applied topically on the affected areas.,Tranexamic acid is an antifibrinolytic,thus we considered it could be effective at this type of rosacea. Methods This is an unblinded study. We included 20 patients, having erythematotelangiectatic rosacea. All patients were women between 27 and 65 years‐old. We divided the patients in two groups,the first group was treated only with tranexamic acid solution (Transamin inj/sol 500 mg/5 mL) infused wet dressing for 20 minutes, and the second group was treated with microneedling simultaneously with tranexamic acid solution topical application followed by tranexamic acid solution infused dressing therapy,every 15 days for four sessions. Results The improvement assecion was outlined according to the Investigator Global Assessment of Rosacea Severity Score (IGA‐RSS) and the use of clinical photos and dermoscopy. All patients were improved in the end of the therapy. There was statistically significant improvement, 2 units IGA‐RSS in the first group, whereas 3 units IGA‐RSS in the second group. The improvement lasted more than four months. The tolerability of the use of tranexamic acid was also asessed. Conclusions According to our results a new really promising simple, safe and cheap treatment option targeting mainly to the vascular net and the erythema of rosacea is proposed.