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Lesional and circulating levels of interleukin‐17 and 25‐hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity
Author(s) -
AbdElmaged Wafaa M.,
Nada Essam A.,
Hassan Mohammed H.,
Elsadek Bakheet E. M.,
Abdelrahim Eman A.,
Ahmed Nagwa S.,
Toghan Rana,
Ahmed Heba T. I.
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12715
Subject(s) - acne , medicine , vitamin d and neurology , pathogenesis , immunohistochemistry , interleukin 17 , gastroenterology , interleukin , endocrinology , vitamin d deficiency , cytokine , dermatology
Summary Objectives The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL‐17 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression. Materials and Methods Across‐sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue levels of IL‐17 and 25(OH)D3, also immunohistochemical and Western blotting demonstration of the expression patterns of lesional IL‐17 in comparison with control group, were performed. Results The mean serum levels of IL‐17 were 544.2 pg/mL ± 477.4 SD and 42.2 pg/mL ± 8.1 SD for acne patients and controls, respectively, with significantly higher levels among the patient group ( P < 0.05). Higher IL‐17 expression levels in active acne lesions when compared with its level in healthy skin of the controls. The mean serum levels of 25(OH)D3 among patients and controls were 33.3 ng/mL ± 9.7 SD and 51.7 ng/mL ± 2.7 SD, respectively, with significantly lower levels among the patient group ( P < 0.05). There were significantly negative correlations between IL‐17 and 25(OH)D3 levels ( P < 0.001 for both). Conclusions Deficiency of vitamin D3 accompanied with higher IL‐17 in an inverse pattern may have a possible role in active acne vulgaris.