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Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne
Author(s) -
Akoglu Gulsen,
Tan Cagman,
Ayvaz Deniz Cagdas,
Tezcan Ilhan
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12558
Subject(s) - acne , medicine , proinflammatory cytokine , genotype , pathogenesis , interleukin , tumor necrosis factor alpha , gastroenterology , dermatology , gene , cytokine , inflammation , biology , genetics
Summary Background Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL‐1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α‐308 G>A and IL‐1β‐511 C .05). Conclusion TNF α‐308 and IL‐1β polymorphic variants are not associated with acne and postacne scarring susceptibility and acne severity.