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The effect of mesenchymal stem cells combined with platelet‐rich plasma on skin wound healing
Author(s) -
MahmoudianSani MohammadReza,
Rafeei Fatemeh,
Amini Razieh,
Saidijam Massoud
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12512
Subject(s) - mesenchymal stem cell , wound healing , stem cell , medicine , platelet rich plasma , multipotent stem cell , cancer research , immunology , pathology , biology , microbiology and biotechnology , platelet , progenitor cell
Summary Introduction Mesenchymal stem cells ( MSC s) are multipotent stem cells that have the potential of proliferation, high self‐renewal, and the potential of multilineage differentiation. The differentiation potential of the MSC s in vivo and in vitro has caused these cells to be regarded as potentially appropriate tools for wound healing. After the burn, trauma or removal of the tumor of wide wounds is developed. Although standard treatment for skin wounds is primary healing or skin grafting, they are not always practical mainly because of limited autologous skin grafting. Evidence Acquisitions Directory of Open Access Journals ( DOAJ ), Google Scholar, PubMed ( NLM ), LISTA ( EBSCO ), and Web of Science have been searched. Evidence Synthesis For clinical use of the MSC s in wound healing, two key issues should be taken into account: First, engineering biocompatible scaffolds clinical use of which leads to the least amount of side effects without any immunologic response and secondly, use of stem cells secretions with the least amount of clinical complications despite their high capability of healing damage. Conclusion In light of the MSC s’ high capability of proliferation and multilineage differentiation as well as their significant role in modulating immunity, these cells can be used in combination with tissue engineering techniques. Moreover, the MSC s’ secretions can be used in cell therapy to heal many types of wounds. The combination of MSC s and PRP aids wound healing which could potentially be used to promote wound healing.