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Vitamin D levels in acne vulgaris patients treated with oral isotretinoin
Author(s) -
ElHamd Mohammed Abu,
El Taieb Moustafa A,
Ibrahim Hassan M,
Aly Sanaa S
Publication year - 2019
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12503
Subject(s) - acne , isotretinoin , medicine , dermatology , vitamin d and neurology , vitamin , pathogenesis , retinoid , gastroenterology , biology , retinoic acid , biochemistry , gene
Summary Background/Objectives Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. This study aimed to assess serum levels of 25 hydroxy vitamin D in patients with acne vulgaris before and after treatment with isotretinoin and its relation with acne vulgaris severity. Methods Ninety patients with acne vulgaris and 60 age‐sex matched healthy subject as controls have been recruited in this study. Patients were treated with 0.75 mg/kg/d isotretinoin for 3 months. Serum level of 25 hydroxy vitamin D has been measured at baseline and after treatment. Results Serum levels of 25 hydroxy vitamin D were significantly higher in patients with acne vulgaris than healthy controls ( P = .001). There was a significant inverse relation between level of 25 hydroxy vitamin D and severity of acne vulgaris before treatment ( P = .001). Serum levels of 25 hydroxy vitamin D were significantly increased after isotretinoin treatment in patients with acne vulgaris ( P = .001). Conclusion This study concluded that vitamin D may play a potential role in pathogenesis of acne vulgaris or acne vulgaris may have a negative effect on vitamin D synthesis. Further studies are needed to confirm these potential relations.