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Cosmeceutical effect of ethyl acetate fraction of Kombucha tea by intradermal administration in the skin of aged mice
Author(s) -
Pakravan Nafiseh,
Mahmoudi Elaheh,
Hashemi SeyedAli,
Kamali Jamal,
Hajiaghayi Reza,
Rahimzadeh Mitra,
Mahmoodi Vajiheh
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12453
Subject(s) - cosmeceutical , ethyl acetate , flavonoid , ethanol , chemistry , skin aging , polyphenol , food science , lanolin , traditional medicine , antioxidant , pharmacology , medicine , biochemistry , dermatology , chromatography , pathology
Summary Background/purpose Natural ingredients have been always an interesting approach to prolong youthful appearance of skin. One of the natural compounds is Kombucha tea (KT), which has been mainly used as an energy drink in Asian countries for a long time. Previous reports indicated that it has pharmaceutical and favorable wound repairing effects. The beneficial properties of KT are thought to be mainly due to the presence of fermentation products such as flavonoids and other polyphenols with inhibition of hydrolytic and oxidative enzymes and anti‐inflammatory effects. These properties prompted us to study the anti‐aging potential of KT and investigate its effective fraction in aged mice, Methods Kombucha tea was fractionated into chloroform, butanol, and ethyl acetate, and flavonoid content was determined. Young and old mice were used as control. KT ethyl acetate fraction ( KEA f), which had the highest flavonoid content, was intradermally administered to old mice. Results Administration of KEA f significantly increased the collagen content, NAD + / NADH level, and concomitantly improved skin connective tissue abnormalities in the aged skin. No sensitivity or irritation was observed. Conclusion This finding suggested that KEA f can be a suitable candidate as a cosmetic product to improve aging‐related skin abnormalities and regeneration of aged skin.