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Comparative study of buffered 50% glycolic acid ( pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris
Author(s) -
In Jae Jeong,
Dong Ju Hyun,
Dong Hyun Kim,
Yoon Moon Soo,
Lee Hee Jung
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12445
Subject(s) - medicine , acne , salicylic acid , lesion , glycolic acid , randomized controlled trial , side effect (computer science) , dermatology , target lesion , prospective cohort study , surgery , biochemistry , lactic acid , chemistry , percutaneous coronary intervention , biology , myocardial infarction , bacteria , computer science , genetics , programming language
Summary Background Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid ( GA ) has been widely used in clinical practice, its pH ranges from 0.08‐2.75 and thus should be neutralized after application to avoid burns. Objective To evaluate treatment efficacy and safety of chemical peeling using buffered 50% GA ( pH 3.0) + 0.5% salicylic acid ( SA ) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution. Methods We performed a prospective, randomized, evaluator‐blind, split‐face clinical trial. Twenty patients were randomized by assigning one side of each patient's face to receive a 50% GA ( pH 3.0) + 0.5% SA peel ( GA side) and the other side to receive the Jessner's solution (Jessner's solution side). All patients underwent 2 sessions of treatment spaced 2 weeks apart. Lesion count, acne severity, subjective efficacy assessment, and side effects were evaluated. Results The total lesion count was significantly reduced for the GA and Jessner's solution sides ( P < .001). However, there was no significant difference in the total lesion count, acne severity, or subjective efficacy assessment between the 2 sides ( P > .05). The GA side had fewer side effects than the Jessner's solution side. Conclusion The results of this study suggest that chemical peeling using the 50% GA ( pH 3.0) + 0.5% SA solution can be as effective and convenient as the conventional peeling using Jessner's solution in the treatment of acne vulgaris and may show fewer adverse events than the conventional peeling.