Premium
Efficacy of subcutaneous injection of platelet‐rich plasma in alopecia: A clinical and histological pilot study on a rat model with a six‐month long‐term follow‐up experience
Author(s) -
Orliac Sophie,
Serfaty JeanMichel,
Perozziello Anne,
Zurlinden Olivier,
Louedec Liliane,
Dallaudière Benjamin
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12425
Subject(s) - platelet rich plasma , medicine , term (time) , dermatology , subcutaneous injection , platelet , surgery , physics , quantum mechanics
Summary Purpose To assess the potential of platelet‐rich plasma ( PRP ) subcutaneous injection of to treat alopecia and to evaluate local toxicity. Materials‐Methods Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). We initiated subcutaneous injection using either PRP in PRPQ +, platelet‐poor plasma ( PPP ) in PPPQ +, physiological serum ( PS ) in PSQ +, or no treatment (Q4). At D7, D14, D21, and D28 but also second month (M2), M3, M4, M5, rats had exactly the same injection procedure. Follow‐up with PRP efficacy and toxicity at D28 and M6 using clinical and histological evaluation was performed. Results Hair density was significantly improved at D28 and at M6 for PRPQ + vs PSQ + (respectively, P = .0156 and P = .0313), PPPQ + (respectively, P = .042 and P = .046). Significant histological improvement was observed between D28 and M6, for PRPQ + vs PPPQ + and PSQ + for vessels (respectively, P = .0160 and P = .021), collagen (respectively, P = .0036 and P = .032), and epithelium (respectively, P = .0138 and P = .022) with no local toxicity. Conclusion Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth.