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Comparative instrumental evaluation of efficacy and safety between a binary and a ternary system in chemexfoliation
Author(s) -
Cameli Norma,
Mariano Maria,
Ardigò Marco,
Corato Cristina,
De Paoli Gianfranco,
Berardesca Enzo
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12424
Subject(s) - transepidermal water loss , stratum corneum , erythema , irritation , chemistry , ternary operation , chromatography , biomedical engineering , dermatology , medicine , pathology , computer science , immunology , programming language
Summary Objective To instrumentally evaluate the efficacy and the safety of a new ternary system chemo exfoliating formulation (water‐dimethyl isosorbide‐acid) vs traditional binary systems (water and acid) where the acid is maintained in both the systems at the same concentration. Methods Different peelings (binary system pyruvic acid and trichloroacetic acid— TCA , and ternary system pyruvic acid and TCA ) were tested on the volar forearm of 20 volunteers of both sexes between 28 and 50 years old. The outcomes were evaluated at the baseline, 10 minutes, 24 hours, and 1 week after the peeling by means of noninvasive skin diagnosis techniques. In vivo reflectance confocal microscopy was used for stratum corneum evaluation, transepidermal waterloss, and Corneometry for skin barrier and hydration, Laser Doppler velocimetry in association with colorimetry for irritation and erythema analysis. Results The instrumental data obtained showed that the efficacy and safety of the new ternary system peel compounds were significantly higher compared with the binary system formulations tested. The new formulation peels improved chemexfoliation and reduced complications such as irritation, redness, and postinflammatory pigmentation compared to the traditional aqueous solutions. Conclusion The study showed that ternary system chemexfoliation, using a controlled delivery technology, was able to provide the same clinical effects in term of stratum corneum reduction with a significantly reduced barrier alteration, water loss, and irritation/erythema compared to traditional binary system peels.