Premium
The efficacy and safety of a monophasic hyaluronic acid filler in the correction of nasolabial folds: A randomized, multicenter, single blinded, split‐face study
Author(s) -
Kwon Hyun Jung,
Ko Eun Jung,
Choi Sun Young,
Choi Eun Ja,
Jang YuJin,
Kim Beom Joon,
Lee Yang Won
Publication year - 2018
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12380
Subject(s) - wrinkle , filler (materials) , rheology , medicine , hyaluronic acid , nasolabial fold , randomized controlled trial , facial rejuvenation , clinical efficacy , surgery , materials science , composite material , gerontology , anatomy
Summary Background The different rheological properties of hyaluronic acid ( HA ) filler reflect their specific manufacturing processes and resultant physicochemical characteristics. However, there are few researches about the relationship between product differences and clinical outcome when HA fillers are used for nasolabial folds ( NLF s). Aims This study sought to compare the rheological properties, efficacy and safety of a monophasic HA filler, and a well‐studied biphasic HA filler, in the treatment of NLF s. Patients/methods A total of 72 Korean subjects with moderate to severe NLF s were randomized to receive injections with monophasic HA or biphasic HA on the left or right side of the face. Efficacy was evaluated by the change in the Wrinkle Severity Rating Scale ( WSRS ) at 2, 10, 18, 26, and 52 weeks. Safety was assessed on the basis of all abnormal reactions during the clinical test period. To compare the rheological characteristics of two cross‐linked HA fillers, viscoelastic analysis was performed. Results At week 26, the mean WSRS was 2.26±0.56 for the monophasic HA side and 2.24±0.54 for the biphasic HA side. Both treatments were well tolerated. The adverse reactions were mild and transient. Monophasic HA filler had lower elasticity and higher viscosity than biphasic HA filler. Conclusion Despite a number of different rheological properties, monophasic HA is noninferior to biphasic HA in the treatment of moderate to severe NLF s for 52 weeks. Therefore, monophasic HA provides an alternative option for NLF s correction.