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Evaluation of the skin phototoxicity and photosensitivity of honeybee venom
Author(s) -
Han Sang Mi,
Hong In Phyo,
Woo Soon Ok,
Kim Se Gun,
Jang He Rye,
Park Kwan Kyu
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12350
Subject(s) - phototoxicity , photosensitivity , erythema , dermatology , medicine , positive control , sensitization , pharmacology , chemistry , immunology , traditional medicine , biochemistry , physics , quantum mechanics , in vitro
Summary Objective Bee ( Apis mellifera L.) venom ( BV ) has been used as a cosmetic ingredient owing to its anti‐aging, anti‐inflammatory, and antibacterial effects. The aim of this study was to assess the skin safety of BV . Methods For this purpose, skin phototoxicity and sensitization tests were conducted in healthy male Hartley guinea pigs. The animals were divided into three groups (n=5) for the phototoxicity test: G1 (negative control), G2 ( BV gel treatment), and G3 (positive control). After specified treatments, the animals were irradiated with ultraviolet A (15 J/cm 2 ). The photosensitivity test was also performed in three groups: G4 (negative control, n=5), G5 ( BV gel treatment, n=10), and G6 (positive control, n=5). Results Erythema and edema were observed after 24, 48, and 72 hours in the positive control group, but not in the negative control and BV gel groups. Application of BV to the guinea pig skin had no toxic effects on any clinical signs, body weight, or mortality. In addition, it did not evoke a skin reaction in both either the skin phototoxicity and skin photosensitization tests. Conclusion Therefore, it can be concluded that BV has the potential to be developed as a drug ingredient for topical uses.