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A review of the role of sebum in the mechanism of acne pathogenesis
Author(s) -
Li Xinchao,
He Congfen,
Chen Zhou,
Zhou Cheng,
Gan Yao,
Jia Yan
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12345
Subject(s) - acne , pathogenesis , medicine , dermatology , secretion , mechanism (biology) , endocrinology , immunology , philosophy , epistemology
Summary Acne is one of the most common skin disorders, and its occurrence is closely related to many factors, including sebum secretion, hormone levels, bacterial infection, and inflammatory reactions. Among these, changes in sebum secretion are believed to be one important factor of acne. Increased sebum secretion can induce acne occurrence, and increasing evidence indicates sebum component changes are also strongly related to acne occurrence. Recently, developments in lipidomics have provided effective lipid analysis methods. These can help elucidate the effects of different types of sebum on acne occurrence and provide a theoretical basis for research on the mechanisms of acne pathogenesis and treatment.