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A randomized, single‐blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face
Author(s) -
Vanaman Wilson Monique J,
Bolton Joanna,
Fabi Sabrina Guillen
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12339
Subject(s) - tripeptide , medicine , erythema , tolerability , randomized controlled trial , regimen , statistical significance , surgery , wrinkle , adverse effect , gerontology , biochemistry , chemistry , amino acid
Summary Background A topical healing system containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™) has been found to stimulate neoelastogenesis and neocollagenesis. Objective Evaluate the use of the tripeptide/hexapeptide topical system following fractionated CO 2 laser resurfacing compared to a bland ointment and cream. Patients/Methods In this single‐blinded, randomized study, 15 female subjects aged 45‐70 years underwent laser resurfacing of the face. Subjects were randomized to use of the tripeptide/hexapeptide system (n=10) or a bland dimethicone‐based ointment and petrolatum‐based cream (n=5) from 3 weeks pre‐ until 12 weeks postprocedure. A blinded investigator graded erythema, edema, crusting, exudation, and healing on postprocedure days 1, 3, 4, 7, 28, and 84. A photodamage/wrinkle scale was completed on days 28 and 84. Subjects performed symptomatology grading on days 1 through 14 and completed self‐assessments at days 28 and 84. Results Data from 14 subjects were analyzed. Blinded‐investigator‐rated healing was better for the tripeptide/hexapeptide system, reaching statistical significance at day 7. The tripeptide/hexapeptide group demonstrated less erythema and exudation during the first postprocedure week, reaching significance at day 3. On days 1 through 14, subjects using the tripeptide/hexapeptide system reported less tenderness and burning/stinging, also reaching significance on day 3. At day 84, subjects using the tripeptide/hexapeptide system reported higher satisfaction and were more likely to recommend the treatment to others. Conclusion Postresurfacing use of a tripeptide/hexapeptide system proved effective and well‐tolerated. Subject satisfaction was greater among those using this system, which may indicate an improved patient experience following laser resurfacing.