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Calcium hydroxylapatite: A review on safety and complications
Author(s) -
Kadouch J.A.
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12326
Subject(s) - erythema , medicine , adverse effect , safety profile , calcium , soft tissue , dermatology , surgery
Summary Background Radiesse ® , or calcium hydroxylapatite (Ca HA ), is a biodegradable, biostimulatory soft tissue filler suitable for deeper folds and wrinkles. In the literature, good results have been documented with the use of Ca HA and patient satisfaction scores are high. This study reviews the current literature on safety and complications of Ca HA . Methods A literature search in MEDLINE /PubMed electronic database was conducted. A total of 21 articles were included and screened for reports of adverse events ( AE s). Results Twenty‐one peer‐reviewed articles, published between 2004 and 2015, were included. A total of 5081 treatments with Ca HA were performed on 2779 patients. A total of 173 (3%) AE s were reported. The assessed types of AE s consisted of nodules (n=166, 96%), persistent inflammation/swelling (n=4, 2%), persistent erythema (n=2, 1%), and overcorrection (n=1, 1%). Conclusion Based on the results in this study, Ca HA appears to have a good safety profile. Nodules are by far the most common AE . Of the reported nodules, 49% occurred in “dynamic” areas currently known for having a higher tendency for nodules. Several treatment approaches exist for managing Ca HA nodules; however, in most cases, Ca HA nodules are not visible and resolve without intervention.