Premium
Dermal morphological changes following salicylic acid peeling and microdermabrasion
Author(s) -
AbdelMotaleb Amira A,
AbuDief Eman E,
Hussein Mahmoud RA
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12315
Subject(s) - dermis , medicine , salicylic acid , dermabrasion , dermatology , masson's trichrome stain , connective tissue , trichrome stain , stain , pathology , surgery , staining , chemistry , immunohistochemistry , biochemistry
Summary Background Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin. Objectives To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion. Methods Twenty patients were participated in our study. All participants underwent facial salicylic acid 30% peel or microdermabrasion (10 cases in each group) weekly for 6 weeks. Punch biopsies were obtained from the clinically normal skin of the right postauricular region 1 week before treatment (control group). Other punch skin biopsies were obtained 1 week after the end of the treatments from the left postauricular area. This region was treated in a similar way to the adjacent lesional skin (treated group). We used routine histological techniques (H&E stain), special stains (Masson trichrome and orcein stains), and image analyzer to study the alterations of the dermal connective tissues. Results Our study demonstrates variations in the morphological changes between the control and the treated groups, and between chemical peels and microdermabrasion. Both salicylic acid 30% and microdermabrasion were associated with thickened epidermal layer, shallow dermal papillae, dense collagen, and elastic fibers. There was a significant increase among those treated sites vs control regarding epidermal thickness and collagen thickness. Also, there was a highly statistically significant increase among those treated with salicylic acid vs microdermabrasion regarding the epidermal, collagen, and elastin thickness. Conclusions Both methods stimulate the repair process. The mechanisms underlying these variations are open for further investigations.