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Acne RA ‐1,2, a novel UV ‐selective face cream for patients with acne: Efficacy and tolerability results of a randomized, placebo‐controlled clinical study
Author(s) -
Cestone Enza,
Michelotti Angela,
Zanoletti Valentina,
Zanardi Andrea,
Mantegazza Raffaella,
Dossena Maurizia
Publication year - 2017
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12309
Subject(s) - tolerability , acne , medicine , dermatology , placebo , transepidermal water loss , adverse effect , randomized controlled trial , regimen , pathology , alternative medicine , stratum corneum
Summary Background General skincare measures such as the use of moisturisers and products containing adequate photoprotection are important components of acne patients’ management to complement the pharmacological regimen. Acne RA ‐1,2 is a novel dermato‐cosmetic product which contains selective photofilters and active ingredients against the multifactorial pathophysiology of acne. Objectives To evaluate the tolerability of Acne RA ‐1,2 and its effect on the clinical signs of acne. Methods This double‐blind, placebo‐controlled study randomized 40 adult patients with 10‐25 comedones per half face to once‐daily application of Acne RA ‐1,2 or placebo for 8 weeks. Evaluations after 4 and 8 weeks included the number of comedones, transepidermal water loss ( TEWL ), sebum production, and tolerability. Results In the Acne RA ‐1,2 group, there was a significant 35% decrease in the mean number of comedones from 26 at baseline to 17 at Week 8 ( P <.001), a 7% significant reduction in TEWL (9.32 to 8.66 g/h/m 2 ; P <.001), and a 24% significant reduction in sebum production (154.8 to 117.6 μg/cm 2 ; P <.001). The reductions in TEWL and sebum production were significantly greater than those in the placebo group at Weeks 4 and 8 ( P <0.05). There were no adverse events. Conclusions Acne RA ‐1,2 was well tolerated and effective at reducing comedones and sebum production and improving epidermal barrier function. These results suggest that Acne RA ‐1,2 is useful against acne‐prone facial skin, particularly as it targets sebum production, which topical pharmacological acne therapies do not address.