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Physiochemical properties and application of hyaluronic acid: a systematic review
Author(s) -
Salwowska Natalia M,
Bebenek Katarzyna A,
Żądło Dominika A,
WcisłoDziadecka Dominika L
Publication year - 2016
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12237
Subject(s) - hyaluronic acid , medicine , adverse effect , randomized controlled trial , pharmacology , surgery , anatomy
Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners. Methods We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria. Findings Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long‐lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved. Conclusions Adjunct therapy with hyaluronic acid provides longer‐lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAID s in osteoarthritic chronic diseases, is well‐established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields.