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Evaluation of anti‐acne property of purified bee venom serum in humans
Author(s) -
Han Sang Mi,
Pak Sok Cheon,
Nicholls Young Mee,
Macfarlane Nicola
Publication year - 2016
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12227
Subject(s) - acne , medicine , dermatology , open label , incidence (geometry) , adverse effect , physics , optics
Summary Objective Acne vulgaris is a chronic dermatologic disease with four factors involved in the development of lesions. Treatments need to address as many of these underlying factors as possible in order to reduce acne lesions. As such, purified bee venom ( PBV ™ ) serum is an attractive therapeutic option for acne, but little data exist on the efficacy of this treatment strategy. Methods In this prospective, noncomparative study, 30 subjects having mild‐to‐moderate acne vulgaris were enrolled and treated with PBV ™ serum twice daily for a period of 6 weeks. Clinical evaluation of lesions by expert visual grading and image analysis were made at weeks 0 (baseline), 3, and 6. Results The average visual acne grade of all volunteers significantly improved with the PBV ™ serum treatment at weeks 3 ( P < 0.05) and 6 ( P < 0.001) when compared with the baseline grade at week 0. In addition, there was a mean percent improvement of 8.6% and 52.3% in acne grade observed after 3 and 6 weeks of PBV ™ serum use, with 20% and 77% of the subjects showing improvement, respectively, when compared with baseline. Moreover, the subjects showed improvement in open comedones, closed comedones, papules, pustules, and nodules after 3 and 6 weeks of PBV ™ serum use. Conclusion Six weeks of treatment with PBV ™ serum was found to be effective in the treatment of mild‐to‐moderate acne vulgaris, with no incidence of serious side effects or irritation.