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Relationship between transient receptor potential vanilloid‐1 expression and the intensity of sensitive skin symptoms
Author(s) -
EhnisPérez Adriana,
TorresÁlvarez Bertha,
CortésGarcía Diego,
HernándezBlanco Diana,
FuentesAhumada Cornelia,
CastanedoCázares Juan Pablo
Publication year - 2016
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12204
Subject(s) - trpv1 , pathogenesis , immunohistochemistry , medicine , capsaicin , transient receptor potential channel , pathology , lesion , receptor , dermatology
Summary Background Sensitive skin ( SS ) is a hyper‐reactive condition of the skin secondary to external factors, without objective signs of lesion. Its pathogenesis is still under investigation. Transient receptor potential vanilloid‐1 ( TRPV 1) is a cation channel that responds to low pH and is related to nociception, neurogenic inflammation, and pruritus. Aims To determine the expression of TRPV 1 in subjects with SS and correlate it with the degree of symptoms and skin pigmentation. Patients/Methods We included 31 subjects self‐diagnosed as having SS . Colorimetric values were obtained for assessment of skin phototype, and the lactic acid stinging test ( LAST ) was performed. Two skin biopsies from the nasolabial fold of each volunteer were obtained. Qualitative analysis of TRPV 1 was carried out with immunohistochemistry. Quantitative analysis of TRPV 1 was carried out with qRT ‐ PCR . Results LAST was positive in 74% of the subjects, 56% of those having tan and brown skin. Immunohistochemistry staining for TRPV 1 was greater in positive subjects ( P = 0.03), but showed no correlation with the intensity of symptoms. Positive subjects also had higher TRPV 1 mRNA expression compared to negative subjects ( P < 0.001). This expression showed a positive correlation with the intensity of referred symptoms ( R = 0.75, P < 0.001) and skin pigmentation ( R = 0.63, P < 0.001). Conclusions TRPV 1 expression is upregulated in subjects with sensitive skin, and it correlates with the intensity of the symptoms. Our findings suggest a role for this receptor in the pathogenesis of sensitive skin syndrome.